College of Staten Island
 The City University of New York
 
  
    
  Alejandra del Carmen Alonso
Professor
Biology

Alejandra del Carmen Alonso
Professor

Office : Building 6S Room 229
Phone : 718.982.4153
Fax : 718.982.3852
alejandra.alonso@csi.cuny.edu


Degrees :
PhD, Universidad Nacional de Córdoba, Argentina





Biography / Academic Interests :
Tau is a key protein in many neurodegenerative diseases, like Alzheimer disease, Frontotemporal dementia, traumatic brain injury, like the one the football players have, to mention some. I have established my group at the College of Staten Island, where we are interested in understanding the process of tau-induced neurodegeneration in cells, and animal models. We have generated novel animal models. We are gaining experience on live cell imaging and molecular biology. The more I learn about Tau, the more I realize that it is a very important protein in the cognitive process and in cell biology in general. We are at the verge of learning about the biology of a very interesting protein that is involved with neurodegeneration, cancer re-expression, DNA protection and mRNA regulation. Tau has been shown to be present in the nucleus, to interact with microfilaments depending on the phosphorylation. Our research will shed light on tau-biology, and will be very useful in the development of new therapeutical approaches for tauopathies. I am eager to contribute to the knowledge of Tau biology and the mechanism of Tau-Induced Neurodegeneration and at the same time, I am glad to think that I will have the opportunity to train new researchers to work in this fascinating area of research and help towards solving Alzheimer’s epidemic.

Scholarship / Publications :
1. Beharry C, Cohen LS, Di J, Ibrahim K, Briffa-Mirabella S and Alonso AD, Tau-Induced Neurodegeneration: Mechanism and target, Neuroscience Bulletin,  30(2): 346–358, 2014.

2. Farid M, Corbo CP, and Alonso AD*.“Tau binds ATP and induces its aggregation”, Microscopy Research and Technique 77(2) 133–137, 2014.

3. Beharry C, Alaniz ME, and Alonso AD .Expression of Alzheimer-like pseudophosphorylated tau at Thr212, Thr231 and Ser262 induces a behavioral motor defect and olfactory learning deficit in Drosophila melanogaster, Journal of Alzheimer Disease, 37, 539-550, 2013.

4. Alonso, AD.#, Di Clerico, J,  Li, B., Corbo, Christopher P. , Alaniz, Maria E. , Grundke-Iqbal I. and Iqbal K. Phosphorylation of tau at Thr212, Thr231 and Ser262 combined and not individually causes neurodegeneration. J. of Biol. Chem. 2010;285(40):30851-60.  

5. Alonso, AD, Bin Li, Inge Grundke-Iqbal and Khalid Iqbal. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies Current Alzheimer Research. 2008 (4):375-84. (Paper Cover of the Journal).

6. Alonso, AD., Li, B., Grundke-Iqbal I. and Iqbal K. Hyperphosphorylated tau from Alzheimer disease brain is toxic only when not polymerized into filaments. Proc. Natl. Acad. Sci. USA. 2006;103(23):8864-9.

7. Alonso, A D., Iqbal, K Tau-induced neurodegeneration: A clue to its mechanism, J of Alzheimer’s disease, 2005;8(3):223-6.