: Building 6S
Ph.D., University of Medicine & Dentistry of NJ
B.Sc., CSI, City University of New York
P.A. Certificate, Sisters of Charity PA Program
Biography / Academic Interests
Dr. Hoover is most interested in the molecular mechanisms of Core Aging. This ubiquitous process occurs in a regular manner across the great diversity of life, yet no one today is absolutely sure of the root cause. Once the core mechanism/s of aging is understood, it may be possible to reverse the process. Hints of age reversal exist in numerous trailblazing studies done by Leonard Guarente, Cynthia Kenyon, Angelika Amon, David Sinclair, and others. Taking the cue from these brilliant researchers, Dr. Hoover’s work focuses upon what he calls “The Protected Template Hypothesis”, in which he believes a resetting occurs at zygotogenesis through an as yet uncovered epigenetic mechanism/s. Dr. Hoover’s work focuses on exploring this hypothesis through the use of model organisms, iPS techniques, as well as stem cell differentiation, dedifferentiation and transdifferentiation.
It is his belief that age impeding-even reversing-technologies are inevitable. Therefore, he is developing ideas related to the ethical aspects of aging research.
Lastly, Dr. Hoover is working to help establish-with others-the field of ‘Theoretical Biology’. TB is modeled after Theoretical Physics in that it will-in part-be founded on mathematics, have venues for logically created hypotheses, and so be an ‘Idea Resource’ for Experimental Biology. But most importantly, TB will be the predictive arm of Biology.
Scholarship / Publications
Hoover DJ, Zhu V, Chen R, Briley K, Rameshwar P, Cohen S, Coffman FD. Expression of the chitinase family glycoprotein YKL-40 in undifferentiated, differentiated, and trans-differentiated mesenchymal stem cells. PLoS One 8(5):e62491, May 2013.
DiCosmo-Ponticello CJ, Coffman FD, Hoover DJ, Cohen S, Cohen MC. Macrophage Migration Inhibitory Factor inhibits monocytic movement in U-937 cells through CXCR4. 2013 (In revision)
Coffman FD, Abassi Y, Wang X, Hoover DJ, Ourfalian K, Cohen MC, Cohen S. Impedance profiles of human breast cancer cells: relationships with genotype and clinical behavior. 2013 (In revision)