Fred Naider

Distinguished Professor

I am an educator with broad experience in the chemical and biochemical sciences. I am interested in peptides, their biology and biochemistry and their role in cell-cell communication. Our laboratory studies the interactions of peptides with membranes and membrane receptors and has published extensively on peptide transport systems, G- protein coupled receptors, isoprenylated peptides and peptides containing tyrosine sulfate. We use peptide surrogates to study complex intermolecular interactions between chemokines and receptors and between gp120 of HIV-1 with receptors.


PhD, Polytechnic Institute of Brooklyn

MS, Cornell University

BS, Cornell University

Scholarship and Publications

10 most recent publications:
1. Srivastava G, Moseri A, Kessler N, Arshava B, Naider F, Anglister J. Defining specific residue-to-residue interactions between the gp120 bridging sheet and the N-terminal segment of CCR5: Applications of transferred NOE NMR. FEBS J. 2018 Oct 5. doi: 10.1111/febs.14673. [Epub ahead of print] PMID: 30288935
2. Lam D, Zhuang J, Cohen LS, Arshava B, Naider FR, Tang M. Effects of chelator lipids, paramagnetic metal ions and trehalose on liposomes by solid-state NMR. Solid State Nucl Magn Reson. 2018 Oct;94:1-6. doi: 10.1016/j.ssnmr.2018.07.002. Epub 2018 Jul 27. PMID: 30096558
3. Abayev M, Rodrigues JPGLM, Srivastava G, Arshava B, Jaremko Ł, Jaremko M, Naider F, Levitt M, Anglister J. The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS J. 2018 Jun;285(11):1988-2003. doi: 10.1111/febs.14460. Epub 2018 Apr 20. PMID: 29619777
4. Hauser M, Qian C, King ST, Kauffman S, Naider F, Hettich RL, Becker JM. Identification of peptide-binding sites within BSA using rapid, laser-induced covalent cross-linking combined with high-performance mass spectrometry. J Mol Recognit. 2018 Feb;31(2). doi: 10.1002/jmr.2680. Epub 2017 Oct 10. PMID:  289942075.

5. Uddin MS, Naider F, Becker JM. Dynamic roles for the N-terminus of the yeast G protein-coupled receptor Ste2p. Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):2058-2067. doi: 10.1016/j.bbamem.2017.07.014. Epub 2017 Jul 25. PMID: 28754538

6. Abayev M, Srivastava G, Arshava B, Naider F, Anglister J. Detection of intermolecular transferred-NOE interactions in small and medium size protein complexes: RANTES complexed with a CCR5 N-terminal peptide. FEBS J. 2017 Feb;284(4):586-601. doi: 10.1111/febs.14000. Epub 2017 Jan 24. PMID: 28052516
7. Moseri A, Sinha E, Zommer H, Arshava B, Naider F, Anglister J. Immunofocusing using conformationally constrained V3 peptide immunogens improves HIV-1 neutralization.  Vaccine. 2017 Jan 5;35(2):222-230. doi: 10.1016/j.vaccine.2016.11.088. Epub 2016 Dec 7. PMID:  27939012
8. Poms M, Ansorge P, Martinez-Gil L, Jurt S, Gottstein D, Fracchiolla KE, Cohen LS, Güntert P, Mingarro I, Naider F, Zerbe O. NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates. J Biol Chem. 2016 Dec 30;291(53):27170-27186. doi: 10.1074/jbc.M116.740985. Epub 2016 Nov 18. PMID:  27864365
9. Sridharan R, Connelly SM, Naider F, Dumont ME. Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast. J Biol Chem. 2016 Nov 11;291(46):24261-24279. Epub 2016 Sep 19. PubMed PMID: 27646004; PubMed Central PMCID: PMC5104947
10. Anglister J, Srivastava G, Naider F. Detection of intermolecular NOE interactions in large protein complexes. Prog Nucl Magn Reson Spectrosc. 2016 Nov;97:40-56. doi: 10.1016/j.pnmrs.2016.08.002. Epub 2016 Aug 18. Review. PubMed  PMID: 27888839.

Contact Information

Office: Building 6S Room 226
Fax: 718.982.3910