Rupal Gupta is an Associate Professor in the Chemistry department and a member of the Chemistry, Biochemistry and Physics PhD programs at the CUNY Graduate Center. Dr. Gupta is interested in studying human antimicrobial proteins using biophysical and spectroscopic methodologies. Memebers of the Gupta lab are investigating both the processes undertaken by pathogens during invasion of a host (human) cell and the responses executed by the host cell during such an attack. The laboratory employs advance magnetic resonance (EPR and solid-state NMR) spectroscopies and computational methodologies to examine events at the interface of chemistry and biology. These studies will provide atomic-level understanding of fundamental processes in the human body during infection.
Degrees
PhD, Carnegie Mellon University
MS, Indian Institute of Technology, Kanpur
Qian Wang, Christopher DiForte, Aleksey Aleshintsev, Gianna Elci, Shibani Bhattacharya, Angelo Bongiorno and Rupal Gupta: "Calcium Mediated Static and Dynamic Allostery in S100A12: Implications for Target Recognition by S100 Proteins", Protein Science, 2024, in press.
Qian Wang, Hanbin Li, Uran Bujupi, Janosch Groning, Andreas Stolz, Angelo Bongiorno and Rupal Gupta: "Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-Substituted Substrate Analog", ChemBioChem, 2024, e202400023.
Qian Wang, Deniz Kuci, Shibani Bhattacharya, Jodi A. Hadden‐Perilla and Rupal Gupta: "Dynamic regulation of Zn(II) sequestration by calgranulin C", Protein Science, 2022, 31(9):e4403.
Qian Wang, Aleksey Aleshintsev, Aneesha N. Jose§, James M. Aramini and Rupal Gupta: "Calcium regulates S100A12 zinc sequestration by limiting structural variations", ChemBioChem, 2020, 21, 1372.
Qian Wang, Aleksey Aleshintsev, David Bolton, Jianqin Zhuang, Michael Brenowitz and Rupal Gupta: "Ca(II) and Zn(II) cooperate to modulate the structure and self-assembly of S100A12", Biochemistry, 2019, 58, 2269-2281.
Aleksey Aleshintsev, Erik Eppinger, Janosch A. D. Gröning, Andreas Stolz and Rupal Gupta: "Substrate promiscuity and active site differences in gentisate 1,2-dioxygenases: electron paramagnetic resonance study", J. Biol. Inorg. Chem., 2019, doi.org/10.1007/s00775-019-01646-5.
