Rupal Gupta is an Assistant Professor in the Chemistry department and a member of the Chemistry, Biochemistry and Physics PhD programs at the CUNY Graduate Center. Dr. Gupta is interested in studying human antimicrobial proteins using biophysical and spectroscopic methodologies. Memebers of the Gupta lab are investigating both the processes undertaken by pathogens during invasion of a host (human) cell and the responses executed by the host cell during such an attack. The laboratory employs advance magnetic resonance (EPR and solid-state NMR) spectroscopies and computational methodologies to examine events at the interface of chemistry and biology. These studies will provide atomic-level understanding of fundamental processes in the human body during infection.
Degrees
PhD, Carnegie Mellon University
MS, Indian Institute of Technology, Kanpur
Roshaan Surendhran, Alexander A. D'Arpino, Bao Y. Sciscent, Alan E. Friedman, Samantha N. MacMilan, Rupal Gupta, David C. Lacy: "Deciphering the mechanism of O2 reduction with electronically tunable non-heme iron enzyme model complexes", Chemical Science, 2018, 9, 5773-5780.
Rupal Gupta and Tatyana Polenova: "Magic angle spinning NMR spectroscopy guided atomistic characterization of structure and dynamics in HIV-1 protein assemblies", Current Opinions in Colloid & Interface Science, 2018, 33, 19-34.
Rupal Gupta, Taketo Taguchi, Benedikt Lassalle-Kaiser, Emile Bominaar, Junko Yano, Michael P. Hendrich, A. S. Borovik: “High-Spin Mn-Oxo Complexes and their Relevance to the Oxygen-Evolving Complex within Photosystem II”, Proceedings of the National Academy of Science of the United States of America, 2015, 112, 5319-5324.
Rupal Gupta, Guangjin Hou, Rokus Renirie, Tatyana Polenova: “51V NMR Crystallography of Vanadium Chloroperoxidase and its Directed Evolution P395D/L241V/T343A Mutant: Protonation Environment of the Active Site”, Journal of the American Chemical Society, 2015, 137, 5618-5628.
Rupal Gupta, David C. Lacy, Emile Bominaar, A. S. Borovik, and Michael P. Hendrich: “Electron Paramagnetic Resonance and Mössbauer Spectroscopy and Density Functional Theory Analysis of a High-Spin FeIV-oxo Complex”, Journal of the American Chemical Society, 2012, 134, 9775–9784.
Rupal Gupta, Rong Fu, Aimin Liu and Michael P. Hendrich: “EPR and Mössbauer Spectroscopy Show Inequivalent Hemes in Tryptophan Dioxygenase”, Journal of the American Chemical Society, 2010, 132, 1098–1109.
