Transition metal homeostasis is one of mechanisms through which the human body combats microbial attack.  We are investigating both the processes undertaken by pathogens during invasion of a host cell and the responses executed by the host cell during such an attack. The research projects aim to study the mechanisms of zinc and copper homeostasis using advance magnetic resonance (EPR and solid-state NMR) spectroscopies and computational methodologies.  Investigation of these physiological events at the interface of chemistry and biology will provide atomic-level understanding of fundamental processes in the human body during microbial invasion.  Such studies will have significant implications for human health and in the design of efficient therapeutics.


PhD, Carnegie Mellon University

MS, Indian Institute of Technology, Kanpur

Scholarship / Publications

Rupal Gupta, et al.: “Dynamic Nuclear Polarization Enhanced MAS NMR Spectroscopy for Structural Analysis of HIV-1 Protein Assemblies”, The Journal of Physical Chemistry B, 2016, 120, 329-339.
Rupal Gupta, Taketo Taguchi, Benedikt Lassalle-Kaiser, Emile Bominaar, Junko Yano, Michael P. Hendrich, A. S. Borovik: “High-Spin Mn-Oxo Complexes and their Relevance to the Oxygen-Evolving Complex within Photosystem II”, Proceedings of the National Academy of Science of the United States of America, 2015, 112, 5319-5324.
Rupal Gupta, Guangjin Hou, Rokus Renirie, Tatyana Polenova: “51V NMR Crystallography of Vanadium Chloroperoxidase and its Directed Evolution P395D/L241V/T343A Mutant: Protonation Environment of the Active Site”, Journal of the American Chemical Society, 2015, 137, 5618-5628.
Rupal Gupta, David C. Lacy, Emile Bominaar, A. S. Borovik, and Michael P. Hendrich: “Electron Paramagnetic Resonance and Mössbauer Spectroscopy and Density Functional Theory Analysis of a High-Spin FeIV-oxo Complex”, Journal of the American Chemical Society, 2012, 134, 9775–9784.
Rupal Gupta, Rong Fu, Aimin Liu and Michael P. Hendrich: “EPR and Mössbauer Spectroscopy Show Inequivalent Hemes in Tryptophan Dioxygenase”, Journal of the American Chemical Society, 2010, 132, 1098–1109.

Last Updated: 01.11.2017